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One major drawback of curcumin is its limited water solubility, making it really challenging as it reduces its target-oriented efficacy and absorption [116]

doi: 10.18632/oncotarget.11110 166 LongB.WangK.LiN.MurtazaI.XiaoJ

(2018) The combined effects of -3 fatty acids and nano-curcumin supplementation on intercellular adhesion molecule-1 (ICAM-1) gene expression and serum levels in migraine patients